Disease of the Month – Sjögren’s Syndrome

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Disease of the Month – Sjögren’s Syndrome


  • A rare autoimmune condition, Sjögren’s Syndrome is characterized by dry mouth and eye. The condition affects 0.5 to 1% of the global population of which 90% of patients are women 
  • In this reprise of our Disease of the Month report, we bring an illuminating account of Sjögren’s Syndrome with deep dive analysis of epidemiology, market size, disease management, available therapies, patient advocacy groups, and the key players involved  
  • For a curated report, reach out to us at connect@pharmashots.com 

A chronic autoimmune disorder characterized by inflammation of the body's moisture-producing glands, Sjögren’s syndrome shows symptoms like dry mouth and eyes. The condition primarily affects the lacrimal glands and the salivary glands.  

Sjögren’s syndrome often coexists with other autoimmune conditions such as lupus and rheumatoid arthritis. It affects mucous membranes and moisture-secreting glands in the mouth and eyes, reducing saliva and tears. Sjögren’s syndrome is typically diagnosed in older women.   

Types of Sjögren’s Syndrome1,2,3,4,6 

There are two types of Sjögren’s Syndrome:  

  • Primary Sjögren’s Syndrome: It develops on its own and isn’t caused by another medical condition  
  • Secondary Sjögren’s Syndrome: It is caused by any other medical condition  


The symptoms of Sjögren’s Syndrome are:  

  • Dry Eyes 
  • Dry Mouth 
  • Vaginal Dryness 
  • Dry skin 
  • Dry nose and frequent nosebleed 
  • Dry throat 

In addition to dryness, Sjögren’s syndrome can cause other symptoms, including: 

  • Joints pain 
  • Muscle pain or weakness 
  • Swollen lymph nodes 
  • Fatigue  
  • Brain fog  
  • Loss of taste 
  • Tooth decay (cavities) or loss 
  • Skin rashes 
  • Neuropathy 
  • Heartburn or other types of indigestion 
  • Light sensitivity 


Sjögren’s syndrome can be triggered by other health conditions and viral infections, such as Hepatitis C, CMV, Epstein-Barr, HTLV, and COVID-19. Secondary Sjögren's syndrome can also be caused by autoimmune diseases like rheumatoid arthritis, psoriatic arthritis, and lupus. 


With symptoms like other medical conditions, it becomes rather difficult to diagnose Sjögren’s syndrome.  

There are some tests that help diagnose Sjögren’s syndrome:  

  • Blood test  
  • Ophthalmological tests  
  • Salivary flow rate  
  • Sialo-gram  
  • Salivary scintigraphy  
  • Chest X-ray or CT scan  
  • Skin biopsy with nerve fiber stain  
  • Urine testing  
  • Biopsy  


According to the Cleveland Clinic report, there are approx. 2 million patients in the United States who have Sjögren’s Syndrome.  

According to NIH, Sjögren’s syndrome has an incidence of approx. one-half of that of rheumatoid arthritis or affecting 0.5% to 1.0% of the population.  

Market Size5 

The global Sjögren’s Syndrome market size was valued at $242.8M in 2023 and is forecasted to reach a value of $330.9M by 2032 at a CAGR of 3.5% between 2023 and 2032. 

Management and Treatment1,2,3,4,6 

The damaged parts of the body determine the course of treatment for Sjögren’s syndrome. Using over-the-counter eyedrops and drinking extra water are common ways that patients with Sjögren’s syndrome can manage their dry mouth and dry eyes. However, some people may require prescription drugs or even surgery.  

  • Prescribed Eyedrops: Restasis (cyclosporine) or Xiidra (lifitegrast) are among the many prescribed eyedrops that help with moderate to severe dry eyes  
  • Saliva-Producing Medications: Salagen (pilocarpine) and Evoxac (cevimeline) are among the many approved saliva-producing medications  
  • Pain Relievers: Over-the-counter pain relievers like nonsteroidal anti-inflammatory drugs (NSAIDs), can help ease pain caused by arthritis symptoms and reduce swellings 
  • Immunosuppressive Medications: Drugs like Plaquenil (Hydroxychloroquine) and Trexall (methotrexate) are among a few safe options that can be prescribed for Sjögren’s syndrome   
  • Surgery: A minor surgical procedure is carried out to cork tear ducts responsible for draining tears from eyes (punctal occlusion)  

Some common treatments for dryness in your eyes, mouth, or vagina include: 

  • Artificial tears 
  • Dry eye surgery 
  • Special mouthwash or dental care products 
  • Vaginal moisturizers or lubricants 
  • Hormone therapy 

Product Dashboard7,8 

Key Players in the Market10

Various pharma giants are working to provide treatment for Sjogren’s Syndrome with only Salagen being approved for treating symptoms of dry mouth in Sjogren's syndrome patients. 

The table below depicts Salagen’s dosage form, dates of approval, and the company marketing the drug.

Clinical Trial Analysis

As of April 23, 2024, about 96 interventional clinical trials have been registered worldwide for Sjögren’s syndrome  

Some of the key molecules involved in the trials are Ianalumab (Novartis), dazodalibep (Amgen), deucravacitinib (BMS), telitacicept (Remegen), efgartigimod (Argenx), AMG-329 (Amgen), iscalimab (Novartis), baricitinib (Eli Lilly), anifrolumab (AstraZeneca).  

Based on the geographical distribution, the interventional and industry-sponsored clinical trials are classified in the below-mentioned graph into two groups based on their status: Active (recruiting, active, not recruiting, not yet recruiting and enrolling by invitation, suspended) and Inactive (withdrawn, terminated, and trials with unknown status).

The maximum number of active trials is being conducted in the China, US, France, Germany, Spain, Canada, Australia, UK, Italy, Korea (as represented in the graph). 

Patient Advocacy Groups (PAGs) for Sjögren’s Syndrome 

Patient advocacy for diseases like Sjögren’s Syndrome can be challenging owing to low prevalence, and limited patient care. Though PAGs are dedicatedly working to address the problems of Sjögren’s Syndrome patients and their families.  


  1. Medical News Today 
  2. Cleavland Clinic  
  3. Mayo Clinic 
  4. WebMd 
  5. Coherent market insight 
  6. Better Health 
  7. Evoxac PI 
  8. Drugs.com 
  9. ClinicalTrial.gov 
  10. Centerwatch

Related Post: Disease of the Month - Duchenne Muscular Dystrophy (DMD) 

Disha Nankani

Disha is a content writer at PharmaShots. She is passionate and curious about recent updates and developments in MedTech and Pharma industry. She covers news related to clinical trial results and updates. She can be contacted at connect@pharmashots.com.

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