Privacy Overview
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Always Active

Necessary cookies are required to enable the basic features of this site, such as providing secure log-in or adjusting your consent preferences. These cookies do not store any personally identifiable data.

No cookies to display.

Functional cookies help perform certain functionalities like sharing the content of the website on social media platforms, collecting feedback, and other third-party features.

No cookies to display.

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics such as the number of visitors, bounce rate, traffic source, etc.

No cookies to display.

Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.

No cookies to display.

Advertisement cookies are used to provide visitors with customized advertisements based on the pages you visited previously and to analyze the effectiveness of the ad campaigns.

No cookies to display.

Skip to content Skip to footer

Know Your Investor: OrbiMed Advisors

Shots: 

  • Know Your Investor’s October Edition focuses on a renowned healthcare investment firm, OrbiMed Advisors, known for making considerable investments in healthcare companies  
  • In 1989, Viren Mehta and Samuel Isaly founded a money management and research organization, an antecedent to OrbiMed. The company made its first investment in 1993  
  • In 2022, OrbiMed Advisors made 31 investments. The highest remains, the investment made to ACELYRIN worth $300M  

OrbiMed Advisors

An American investment firm, OrbiMed Advisors is a renowned name among the various venture capital firms. The company primarily makes public and private investments in the Healthcare and Biotechnology sectors. With headquarters in New York City, United States, today OrbiMed has a global presence among major pharma and biotech companies.  

In 1989, Viren Mehta and Samuel Isaly established Mehta & Isaly as a money management and research organization. Later in 1998, Mehta & Islay dissolved into two distinct businesses: OrbiMed, which came from Islay, and Mehta Partners, which came from Mehta.   

OrbiMed expanded its presence in Asia by opening offices in Shanghai and Mumbai in 2007 and the Middle East with a new inauguration in Herzliya, Israel. 

In addition to Series A, B, C, and D rounds, OrbiMed was primarily linked to common fundraising investments in 2022. With the help of many investment rounds, the company has an extensive portfolio of companies, including Adicet Bio, Arcutis, Bionova Pharmaceuticals, Compass Therapeutics, Edgewise Therapeutics, Fusion Therapeutics, and Netmeds.com, among others. The organization made 31 investments in 2022 with the highest investment made to ACELYRIN for a total of $300M.   

The majority of OrbiMed’s investments in 2022 went to biopharma companies, including Apogee Therapeutics Inc., Compass Therapeutics LLC, Enliven Therapeutics Inc., and VectivBio AG (Ironwood) among others. Device, Diagnostics, and Manufacturing/Services were other areas in which OrbiMed invested. Furthermore, the company has also invested in a vast spectrum of technologies, including Antibody Drugs, Artificial Intelligence (AI), Machine Learning (ML), Cell Therapy, Digital Health, Gene Editing/CRISPR, Gene Therapy, Immunotherapy, Peptide, RNA Therapies, Small Molecule, Stem Cell, etc. OrbiMed had the highest investments made in the company developing small molecules or antibody drugs.   

Of the total investments made by OrbiMed in 2022, 42% of the investments were made under Series A financing, whereas 30% was made under Series B financing. The top 3 investments made by OrbiMed were as follows:  

  1. Series C funding worth $300M to ACELYRIN Inc. 
  2. Series B funding worth $225M to DELFI Diagnostic Inc. 
  3. Series A funding worth $200M to Upstream Biosciences Inc. 

Additionally, OrbiMed took part in roughly 10 funding rounds in the first quarter of 2022, 8 in the second, 3 in the third, and 10 in the last quarter. Biopharma companies, including Apogee Therapeutics Inc., Compass Therapeutics LL, Enliven Therapeutics Inc., and VectivBio AG (Ironwood) received the largest amount of investment out of this financing made by the firm in 2022. In addition, OrbiMed made investments in Alpheus Medical Inc., Upstream Biosciences Inc., and MDClone, among other companies.  

OrbiMed made significant investments in companies that develop therapeutics that target indications under oncology. DELFI Diagnostic Inc. received $225 million from OrbiMed in total while Enliven Therapeutics Inc. received $165 million, ImmPACT Bio Inc. received $111 million, and Capstan Therapeutics received $102 million.  

The table below showcases the top 5 funding rounds out of the 31 investments made by OrbiMed Advisors in 2022. (For a complete report, reach out to us at connect@pharmashots.com with the subject line “OrbiMed Advisors Data”) 

Related Posts: Know Your Investor: F-Prime Capital Partners 

Sign Up to Our Newsletter

Be the first to know the latest updates

[mc4wp_form id="13387" element_id="style-1"]