BMS Receives the US FDA’s Breakthrough Designation for BMS-986278 to Treat Pulmonary & Progressive Pulmonary Fibrosis (IPF & PPF)
Shots:
- The designation was granted based on the results from the P-II clinical trial evaluating the safety & efficacy of BMS-986278 (30/60mg, BID) vs PBO for 26wks. in patients with IPF & PPF. The rate of change in ppFVC from baseline to 26wks. was evaluated as 1EP in IPF cohort & as 2EP in PPF cohort
- As per the results, a 69% relative reduction in the rate of change in ppFVC vs PBO was seen in the PPF cohorts receiving BMS-986278 (60mg, BID) with treatment effects consistent with/out background therapy & rates of AEs similar to PBO. The results were presented at the ESR 2023
- BMS-986278 is an oral small molecule LPA1 antagonist that is being evaluated as an antifibrotic for the treatment of IPF & PPF
Ref: Businesswire | Image: BMS
Related News:- BMS to Present P-II Study Results of BMS-986278 for Progressive Pulmonary Fibrosis at ERS 2023
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Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.
