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Incyte Presents Positive 52-Week P-IIb Trial Results of Povorcitinib (INCB54707) for Extensive Nonsegmental Vitiligo at EADV 2023

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Incyte Presents Positive 52-Week P-IIb Trial Results of Povorcitinib (INCB54707) for Extensive Nonsegmental Vitiligo at EADV 2023

Shots:

  • The new 52wk. results from a P-IIb trial evaluating povorcitinib in a ratio (1:1:1:1) in 171 patients aged 18-75yrs.
  • The results showed mean percentage total body & facial depigmentation improvement from baseline as measured by T-VASI & F-VASI  at 52wk. for povorcitinib 15-75mg, 45mg, 75mg, and PBO-to-75mg were 40.7% & 63.6%, 42.7% & 63.8%, 41.3% & 64.4% and 18.1% & 54.8%, respectively
  • The 2EPs results incl. ≥50% reduction from baseline in T-VASI (T-VASI50) vs initial results at 24wk. for povorcitinib 15-75mg, 45mg, 75mg and PBO-to-75mg were 45.2%, 37.0%, 37.9% and 15.2%; ≥50% & >75% in F-VASI (F-VASI50 and F-VASI75) were 71.0% & 48.4%, 77.8% & 55.6%, 69.0% & 58.6% and 63.6% & 45.5%, TEAEs of any grade were seen in 89.2% of 83 patients who received 45 or 75 mg doses

Ref: Business wire | Image: Incyte

Related News:- Replimune Entered into Clinical Trial Collaboration and Supply Agreement with Incyte to Evaluate RP1 + INCB99280 for Cutaneous Squamous Cell Carcinoma

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Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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