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Regeneron and Sanofi Presented P-III Trial (BOREAS) Results of Dupixent (dupilumab) for Chronic Obstructive Pulmonary Disease at ATS and Published in the NEJM

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Regeneron and Sanofi Presented P-III Trial (BOREAS) Results of Dupixent (dupilumab) for Chronic Obstructive Pulmonary Disease at ATS and Published in the NEJM

Shots:

  • The P-III trial evaluating Dupixent vs PBO added to maximal SoC inhaled triple therapy in 939 adult patients aged 40-80yrs.
  • The trial met its 1EPs & 2EPs i.e., 30% reduction in mod. to sev. COPD exacerbations @52wks., numerical improvement as early as 2wks. & benefits were sustained @52wks., 9.7 vs 6.4-point improvement in health-related QoL from baseline with numerical improvements as early as 4wks. & reduction in respiratory symptom severity (2.7 vs 1.6-point) @52wks.
  • The safety results were consistent with the known safety profile of Dupixent, overall rates of AEs (77% vs 76%), and AEs leading to deaths (1.5% vs 1.7%). The P-III trial (NOTUS) of Dupixent is ongoing for COPD with evidence of type 2 inflammation & results are expected in 2024

Ref: Globenewswire | Image: Regeneron

Related News:- Sanofi and Regeneron Report P-III Trial (PRIME) and (PRIME2) Results of Dupixent (dupilumab) for the Treatment of Prurigo Nodularis

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Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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