MorphoSys and Incyte Presents Five-Year P-II Study (L-MIND) Results of Monjuvi (tafasitamab-cxix) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma AACR 2023
Shots:
- The P-II study evaluating tafasitamab + lenalidomide in 81 patients who had one but no more than 3 prior lines of therapy, incl. an anti-CD20 targeting therapy who were not eligible for high-dose CT or refused subsequent autologous SCT
- At data cut-off of Nov 2022, the therapy showed ORR (57.5%), CR (41.2%); PR (16.2%) & additional results incl. mDoR (not reached) after a median follow-up of 44.0mos., m-OS (33.5mos.) & m-PFS (11.6mos.). Among 21 patients with >60mos. of follow-up, 14 had received 1 prior line of therapy (pLoT) & 7 with ≥2 pLoT
- Patients achieved higher ORR (67.5%) with 1 pLoT (CR = 52.5% & PR = 15%) vs 47.5% with 2 pLoT (CR = 30% & PR = 17.5%) with no new safety signals, patients experienced a lower frequency of all-grade & grade ≥3 AEs during monotx.
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Related News:- MorphoSys Reports the Completion of Patient Enrollment in P-III Study (MANIFEST-2) of Pelabresib for Myelofibrosis
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