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Vertex Collaborated with Entrada Therapeutics to Develop Endosomal Escape Vehicle Therapies for Myotonic Dystrophy Type 1

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Vertex Collaborated with Entrada Therapeutics to Develop Endosomal Escape Vehicle Therapies for Myotonic Dystrophy Type 1

Shots:

  • Entrada will receive $224M up front, $26M in equity investment, and ~$485M upon achievement of research, development, regulatory & commercial milestones along with royalties on net sales of products
  • Entrada will continue to advance research activities related to ENTR-701 and additional DM1-related research activities. Vertex will lead the global development, manufacturing & commercialization of ENTR-701 along with an additional program from Entrada’s DM1 research efforts
  • The agreement includes a 4yr. research collaboration along with ENTR-701 (currently in late-stage preclinical development) for DM1. The preclinical studies of ENTR-701 suggested the correction of disease-relevant biomarkers in multiple muscle groups

Ref: Businesswire Image: Vertex

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