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Celltrion Reports P-III Trial Results of CT-P16 (biosimilar, bevacizumab) for Non-Squamous Non–Small Cell Lung Cancer

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Celltrion Reports P-III Trial Results of CT-P16 (biosimilar, bevacizumab) for Non-Squamous Non–Small Cell Lung Cancer

Shots:

  • The P-III trial evaluating CT-P16 vs EU-Approved Avastin (15mg/kg, q3w; ≤ 6 cycles) with paclitaxel (200mg/m2) & carboplatin in 689 patients with metastatic or recurrent non-sq. NSCLC across 164 study sites in 21 countries     
  • CT-P16 showed an equivalent efficacy & similar PK, safety, and immunogenicity to reference EU-bevacizumab. In the primary efficacy EPs, ORR (42.40% vs 42.07%); CR (0.6% vs 0.9%); PR (41.8% vs 41.2%) while the 2EPs incl. response duration (7.2 vs 6.3mos.), m-TTP, PFS, and OS were also similar
  • Patients experienced ≥1 TEAEs (96.2% vs 93%); TEAEs considered to be related to the use of bevacizumab (51.6% vs 50.6%); patients were positive for antidrug Abs (22.6% vs 24.1%) regarding immunogenicity

Ref: Centerforbiosimilar | Image: Celltrion

Related News:- Celltrion Healthcare Receives CHMP Positive Opinion of CT-P16 (biosimilar, bevacizumab) as 1L Treatment of Non-Squamous Non-Small Cell Lung Cancer

Click here to­ read the full press release 

Neha

Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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