AbbVie Reports Exploratory P-II (NOVA) Trial Results of AGN-151607 for the Prevention of Postoperative Atrial Fibrillation in Cardiac Surgery Patients
Shots:
- The exploratory P-II (NOVA) dose-ranging study evaluates AGN-151607 in patients with POAF undergoing open-chest cardiac surgery
- The 1EPs were not met for evaluating the occurrence of continuous AF ≥30 seconds for the mITT population, relative risk reduction was observed in specific study populations i.e., CABG patients and in patients aged ≥65yrs. with 29% relative risk reduction over PBO
- In a post hoc analysis, patients treated with 125 units of AGN-151607 showed a 51% greater risk reduction with lower rates of all-cause re-hospitalization within 30 days over PBO (8.7% vs 15.7%) while 62.9% vs 45.1% were atrial fibrillation-free and anticoagulation-free, treatment discontinuation due to AE and rates of AEs were numerically similar across the three treatment groups
Ref: AbbVie | Image: AbbVie
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