Puma Biotechnology Presents P-II (SUMMIT) Basket Trial Results of Neratinib for EGFR Exon 18-Mutant NSCLC at EORTC/NCI/AACR 2022
Shots:
- The P-II (SUMMIT) basket trial evaluating neratinib in 582 patients with EGFR exon 18-mutant NSCLC. 79% of patients prior treated with an EGFR-targeted TKI
- In an interim efficacy, the therapy showed ORR (35%), 30% of patients pretreated with TKIs, and 50% not pretreated with TKIs, response or SD lasting for ≥ 48wks. was observed in 7 patients (6 PR, 1 SD), 3% permanently discontinued the treatment due to diarrhea
- Neratinib was approved in the US for early-stage HER2-overexpressed/amplified breast cancer & is marketed as Nerlynx. The therapy was also approved in the US in combination with capecitabine for advanced or metastatic HER2+ breast cancer & has received EC's marketing authorization for early-stage HR+ HER2-overexpressed/amplified breast cancer
Ref: Businesswire | Image: Puma Bio
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