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BridgeBio Pharma Initiates P-III Study (CALIBRATE) of Encaleret for Autosomal Dominant Hypocalcemia Type 1

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BridgeBio Pharma Initiates P-III Study (CALIBRATE) of Encaleret for Autosomal Dominant Hypocalcemia Type 1

Shots:

  • The company initiated the P-III study (CALIBRATE) evaluating the efficacy & safety of encaleret vs SoC in a ratio (2:1) in 45 patients aged ≥16yrs. with biochemical evidence of hyperparathyroidism & genetic confirmation of ADH1 for 24wks.
  • In an ongoing P-IIb study, 92% achieved normal blood calcium levels in the absence of SoC, and 77% had achieved normal 24-hr urinary calcium excretion within the normal range @24wk. of outpatient treatment, was well-tolerated with no observed safety signals of clinical concern, and restored normal mineral homeostasis. The results were presented at ENDO 2022
  • Encaleret has received FTD in the US while ODD in the US & EU. If encaleret is approved, it will be the first therapy indicated for ADH1

Ref: - Globenewswire | Image: BridgeBio Pharma

Related Posts:-  BridgeBio Pharma Presents P-I/II (CANaspire) Trial Results of BBP-812 for the Treatment of Canavan Disease at CNS 2022

Click here to­ read the full press release 

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Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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