Roche's Tecentriq + Cotellic and Zelboraf Receives the US FDA's Approval for Patients with Advanced Melanoma
Shots:
- The approval is based on P-III IMspire150 study assessing Tecentriq (atezolizumab) + Cotellic (cobimetinib) + Zelboraf (vemurafenib) vs PBO + Cotellic + Zelboraf in patients with BRAF V600 mutation-positive advanced melanoma
- Results: mPFS (15.1 vs 10.6mos.); the safety profile of the Tecentriq combination was consistent with the known safety profiles of the individual medicines. The review was conducted under Project Orbis
- Tecentriq is a mAb targeting PD-L1- acts by blocking is its interactions with both PD-1 and B7.1 receptor. Cotellic is a MEK1/2 inhibitor in a cell signaling pathway that helps control cell growth and survival while Zelboraf is a prescription medicine for melanoma that has spread to other parts of the body or cannot be removed by surgery and has a BRAF V600 mutation
Ref: Roche | Image: Roche
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