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BMS Reports Results from the P-III (CheckMate -8HW) Study of Opdivo (nivolumab) + Yervoy (ipilimumab) for Metastatic Colorectal Cancer (mCRC)

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BMS Reports Results from the P-III (CheckMate -8HW) Study of Opdivo (nivolumab) + Yervoy (ipilimumab) for Metastatic Colorectal Cancer (mCRC)

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  • BMS highlights results from the P-III (CheckMate -8HW) study of Opdivo (240mg, followed by 480mg, Q4W) + Yervoy (1mg/kg, Q3W, 4 doses) vs Opdivo (240mg, Q2W, 6 doses, followed by 480mg, Q4W) as monotx. or CT (mFOLFOX-6/FOLFIRI with/without bevacizumab/cetuximab) for the 1L treatment of MSI-H/dMMR mCRC patients (n=830), at ASCO GI 2024
  • The results reveal that the combination showed improved PFS of 79% at ~3mos., mPFS was not attained vs 5.9mos. in the CT arm. Consistent PFS benefit was seen in patients with KRAS or NRAS mutations & baseline liver, lung, or peritoneal metastases. OS is being evaluated
  • The safety profile of the combination was consistent, grade 3/4 TRAEs were seen in 23% vs 48% and the grade TRAE-related discontinuation occurred in 17% vs 32% in the CT arm

Ref: BMS | Image: BMS

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Shivani Chandra

Shivani was a content writer at PharmaShots. She has a keen interest in recent innovations in the life sciences industry. She was covering news related to Product approvals, clinical trial results, and updates. We can be contacted at connect@pharmashots.com.

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