AnaptysBio Reports P-III Trial (GEMINI-1) Results Of Imsidolimab (Il-36r) for Generalized Pustular Psoriasis
Shots:
- The P-III trial evaluating imsidolimab (IL-36R mAb) vs PBO in 45 patients with GPP flares. The trial met its 1EPs & achieved rapid clearance of pustulation, erythema & scaling through 4wk. after a single dose of imsidolimab (750mg, IV)
- 53.3% vs 13.3% achieved GPPPGA 0/1 (clear or almost clear) at 4wk. who received a single dose of imsidolimab, 66.7% of PBO patients exited (GEMINI-1) early, crossed over to (GEMINI-2) & were eligible to receive rescue therapy with a favorable safety & tolerability profile with no SAEs or sev. AEs, 3.3% had detectable anti-drug Abs which were non-neutralizing
- The company plans to present comprehensive data from (GEMINI-1) and top-line (GEMINI-2) results at a medical meeting in H2’24 along with planning to file the BLA with the US FDA in Q3’24
Ref: AnaptysBio | Image: AnaptysBio
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