Novo Nordisk Reports P-III Trial (STEP-HFpEF) Results of Semaglutide for Heart Failure with Preserved Ejection Fraction and Obesity
Shots:
- The P-III trial evaluating semaglutide (2.4mg, qw) vs PBO in 529 patients, showed a large reduction in HF-related symptoms, physical limitations, and improvements in exercise function resulted in greater weight loss in adults with HFpEF & obesity, a large improvement in patient-reported KCCQ-CSS
- Mean change in the KCCQ-CSS at 52wks. (16.6 vs 8.7 points); body weight reduction (13.3% vs 2.6%); an increase in 6MWD of 21.5 vs 1.2 meters at 52wks. The safety profile was consistent with prior studies with fewer serious AEs
- The results were presented at the ESC Congress in Amsterdam, Netherlands & published in the NEJM. The (STEP HFpEF-DM) study is expected to be completed in Q4’23 while the company plans to file for approval of the Wegovy label update in the US & EU in H1’24
Ref: Novo Nordisk | Image: Novo Nordisk
Related news:- Novo Nordisk Reports P-IIIa Trial (OASIS 1) Results of Semaglutide for the Treatment of Obesity or Overweight
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