Horizon Published P-IV (MIRROR) Trial Results of Krystexxa (pegloticase) for the Treatment of Uncontrolled Gout in Arthritis & Rheumatology
Shots:
- The P-IV (MIRROR) randomized controlled trial evaluates Krystexxa + methotrexate vs Krystexxa + PBO in a ratio (2:1) in 152 patients with uncontrolled gout
- The 1EPs of the study were the proportion of serum uric acid (sUA) responders @6mos. (20-24wks.) & the 2EPs included the proportion of sUA responders @12mos. (48-52wks.)
- The results showed a ≥30% point increase in patient response rate @6mos., patients achieved the primary efficacy EPs (71% vs 39%), reduction in infusion reactions from 31% to 4% with no new safety signals., 20%-point increase in the complete resolution of 1 tophus @24wks. (35% vs 14%), 76% had investigator-identified tophi, and all experienced 1 gout flare in the prior year
Ref: Horizon | Image: Horizon
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