Asthma is a widespread disease that affects around 10 per cent of Sweden?s population. Approximately half the affected people have so-called uncontrolled asthma and frequently experience breathing difficulties or asthma attacks. Inadequate management and/or incorrect use of medicines are common causes of this. ?Previous research has shown that asthma sufferers? health and quality of life improves with patient education that focuses on self-care, self-testing and clear management plans. Additionally, health and medical care costs fall if patient involvement and knowledge can be leveraged,? states Bj?rn Nordlund, paediatric nurse and research group leader at the Department of Women?s and Children?s Health, Karolinska Institutet, Sweden.

Automated, self-care system

Consequently, along with his colleagues, Bj?rn Nordlund developed a digital, automated, self-care system for asthma. Called AsthmaTuner, it enables the measuring of lung function via a wireless spirometer connected to a mobile telephone app. Symptoms are evaluated using questions linked to an individual treatment plan. The system was approved for use in medical care in 2018. It is now marketed by MediTuner AB, a company partly owned by Bj?rn Nordlund. ?The system analyses lung function and symptoms in accordance with asthma-care guidelines,? he explains. ?It then gives feedback in the form of automated, doctor-prescribed, treatment recommendation. Users also receive a picture of the inhaler that is to be used and instructions on whether the medication is to be maintained, increased or decreased.?

The now published study was carried out in primary care and at the Astrid Lindgren Children?s Hospital in Stockholm, Sweden. Its purpose was to evaluate the digital tool?s impact on symptoms and whether users more readily remembered to take their medicines. The study comprised 77 uncontrolled asthma sufferers aged 6 upwards. Around half of these were children and adolescents. Study participants were randomly chosen to use AsthmaTuner for at least eight weeks as a support for self-management; and, also for at least eight weeks, receive traditional asthma care with a printed, individual, treatment plan.

Asthma symptoms improved

?In parts, the results were hard to interpret. However, we could see that asthma symptoms improved more with the digital tool than they did with traditional care. Adult patients who used the tool at least once a week also more often remembered to take their medicines. Thus, we conclude that this tool can contribute to alleviating uncontrolled asthma sufferers? symptoms,? says Bj?rn Nordlund. As asthma requires long-term, regular management, the researchers regarded the shortness of the study as a weakness. Hence the plans to continue the work. ?We do not know if the effects last longer than eight weeks. Thus, we are starting a larger study this autumn. It will run for a longer period and be conducted in Norrt?lje?s Tiohundra medical care district and paediatric medical care in Stockholm (the Astrid Lindgren Children?s Hospital).? AsthmaTuner was developed in collaboration with Region Stockholm and KI Innovations AB. Clinical testing was administered by Karolinska Trial Alliance. The present study was financed by funding from Uppsala Bio, Region Stockholm?s innovation fund, Capio?s research fund, Vinnova (Sweden?s innovation agency) and MediTuner AB. Henrik Ljungberg was the study?s first author. He, like Bj?rn Nordlund, is a co-founder of MediTuner AB, which owns AsthmaTuner.

Publication

?Clinical effect on uncontrolled asthma using a novel digital automated self-management solution: a physician-blinded randomised controlled crossover trial?, Henrik Ljungberg, Anna Carleborg, Hilmar Gerber, Christina ?fverstr?m, Jakob Wolodarski, Faiza Menshi, Mikaela Engdahl, Marianne Eduards, Bj?rn Nordlund,?European Respiratory Journal, online 3 September 2019, doi: 10.1183/13993003.00983-2019.