Under the multi-year collaboration, Tango will perform target discovery and validation and Gilead will have options to worldwide rights on up to five targets emerging from Tango?s proprietary functional genomics-based discovery platform. For two programs directed to these targets, Tango will retain the option to co-develop and co-detail in the U.S. The collaboration does not include Tango?s lead programs, for which Tango will retain all rights. Gilead Chief Scientific Officer and R&D head John McHutchison said: ?Tango has built a unique discovery platform that we hope will help create the next generation of cancer therapies. ?Our collaboration will combine Tango?s innovative discovery technology alongside Gilead?s drug discovery and development capabilities to build a pipeline of novel immuno-oncology therapies.? Tango president and CEO Barbara Weber said: ?Gilead is the ideal partner to help us bring potentially transformative treatments to patients with cancer. ?This partnership has significant strategic value for us. With Gilead as our partner, we can maximize the applications of our platform in immuno-oncology, while continuing to independently advance our lead programs into the clinic and beyond.? Under the terms of the agreement, Tango will receive an upfront payment of $50 million. Tango will also be eligible to receive approximately $1.7 billion in total additional payments across all programs in the form of pre-clinical fees and development, regulatory and commercial milestone payments; and up to low double-digit tiered royalties on net sales.