GlaxoSmithKline plc today announces a major 3-part inter-conditional transaction with Novartis AG involving its Consumer Healthcare, Vaccines and Oncology businesses (the ?Transaction?). In summary:

• GSK and Novartis will create a new world-leading Consumer Healthcare business with 2013 pro forma revenues of ?6.5 billion. GSK will have majority control with an equity interest of 63.5%
• GSK will acquire Novartis? global Vaccines business (excluding influenza vaccines) for an initial cash consideration of $5.25 billion with subsequent potential milestone payments of up to $1.8 billion and ongoing royalties
• GSK will divest its marketed Oncology portfolio, related R&D activities and rights to its AKT inhibitor and also grant of commercialisation partner rights for future oncology products to Novartis for an aggregate cash consideration of $16 billion (of which up to $1.5 billion depends on the results of the COMBI-d trial)
• GSK shareholders to receive ?4 billion capital return funded by net cash transaction proceeds and expected to be delivered via a B share scheme
• Transaction expected to be accretive to core EPS from first year, reflecting execution of intended B share scheme, and thereafter with growing contribution from 2017 as projected cost savings and new growth opportunities are delivered
• Transaction is expected to complete during the first half of 2015 subject to approvals

Sir Andrew Witty, Chief Executive Officer, GSK said:? ?This proposed 3-part transaction accelerates our strategy to generate sustainable, broadly sourced sales growth and improve long-term earnings. ?Opportunities to build greater scale and combine high quality assets in Vaccines and Consumer Healthcare are scarce. With this transaction we will substantially strengthen two of our core businesses and create significant new options to increase value for shareholders. ?The Novartis OTC portfolio is highly complementary to GSK?s and has many well-known, widely recommended brands such as Voltaren, Excedrin, Otrivin, andTheraflu. Together, we will create the world?s premier OTC business with clear opportunities to accelerate revenue growth. ?The acquisition of Novartis? Vaccines business will significantly enhance the breadth of our vaccines portfolio and pipeline, notably in meningitis, with the addition of Bexsero, an exciting new vaccine for prevention of meningitis B. The acquisition will also strengthen our manufacturing network and reduce supply costs. ?The third part of this transaction would see divestment of our Oncology portfolio to Novartis.? Over the last six years we have made excellent progress to develop a series of innovative medicines. This transaction provides us with a unique opportunity to crystallise an attractive value for this portfolio and allow these medicines to benefit from Novartis? global scale in this area. In financial terms, this transaction significantly exceeds our return criteria and delivers accretion to core earnings per share in year one and then with a growing contribution over time, particularly in 2017, as growth opportunities and projected cost savings are delivered. ?We also expect to return ?4 billion to shareholders following completion of this transaction, whilst maintaining a strong capital base and our commitment to increasing dividends. ?Finally, and very importantly, this transaction strengthens GSK?s offering to patients and consumers. We will expand our portfolio to both help treat illness and prevent disease, and we will broaden our scope to improve human health with the acquired R&D and innovation expertise.? Strategic highlights Balanced set of core businesses and strengthened R&D The proposed Transaction would increase GSK?s annual revenues by ?1.3 billion to ?26.9 billion (on a 2013 pro forma basis) and fundamentally re-shape GSK?s revenue base. These revenues would be split across Pharmaceuticals 62%, Consumer Healthcare 24% and Vaccines 14%. Following completion, around 70% of GSK?s revenues would be focussed around four key franchises: Respiratory, HIV (ViiV Healthcare), Vaccines and Consumer Healthcare. All of these franchises operate in growing markets with new and market-leading brands and products manufactured in protected technologies. Of the remaining revenue base, approximately 14% of sales would reside in GSK?s Established Products Portfolio (EPP). GSK is currently reviewing this portfolio to ensure the Group evaluates all options to maximise its value. As a result of this transaction, GSK?s late-stage development pipeline would be further strengthened with the addition of 4 new candidate vaccines from Novartis. In total, GSK would have around 45 NMEs in Phase II/III clinical development. In Consumer Healthcare, both GSK and Novartis have strong track-records of brand innovation and creating scientifically differentiated products with ~15% of combined sales generated from innovation launched in recent years. Creating a new world-leading Consumer Healthcare business Following completion of the transaction, GSK will be a global leader in Consumer Healthcare with revenues of ?6.5 billion, on a 2013 pro forma basis. The new business will hold category leading positions and brands in Wellness, Oral health, Nutrition and Skin health, combining OTC and FMCG capabilities and expertise. In Wellness, the new combination?s ?3.4 billion complementary portfolio will create the world?s largest OTC business with the leading position in more than 35 countries around the world. The combination is geographically well-matched. Novartis? portfolio has had relatively limited exposure to high growth emerging markets and this presents multiple new growth opportunities for several major brands and innovations, notably Voltaren, Excedrin and Otrivin. Similarly, GSK?s brands would benefit from exposure to Novartis? highly successful CIS, Central and Eastern European business. The combination also creates a more competitive business.? With leading positions in most of the categories in which it operates, the combination will have excellent customer insight and ability to offer retailers better shopper experiences. The combination will also have significant mass market, pharmacy and expert selling capabilities with sales personnel throughout the world. The business will also have access to world-leading science capabilities and to new Rx/Cx switch opportunities from both parent companies. Emma Walmsley has been appointed as Chief Executive Officer Designate of the new business and will be a member of its Board. Sir Andrew Witty will be Chairman of the Board. The Board will comprise directors from both GSK and Novartis. Strengthening global leadership in Vaccines The acquisition of Novartis? global Vaccines business (excluding influenza vaccines) further improves GSK?s position as the world?s leading global vaccines supplier. Demand for vaccination remains significant with the global vaccine market projected to grow approximately 10% per annum over the next 10 years. The transaction will strengthen the breadth of GSK?s portfolio, notably in meningitis, including the addition of Bexsero, a new vaccine for prevention of meningitis B and a further candidate vaccine in late-stage development, MenABCWY. This portfolio expansion will be of benefit to GSK in all markets and notably in the USA, where Novartis has a strong track record of delivery. GSK?s significant presence in emerging and developing markets will also provide new opportunities for introduction and growth of Novartis? vaccines. GSK and Novartis? Vaccines R&D organisations are highly complementary, bringing together respective expertise in virology, bacterial infection and different adjuvant platforms. The new business would have more than 20 different vaccines in development, including assets to prevent hospital and maternal infections and diseases prevalent in developing countries such as malaria and tuberculosis. The acquisition is expected to strengthen GSK?s manufacturing network and increase overall capacity, notably with the addition of Novartis? secondary packaging and supply facilities in Rosia, Italy and Marburg, Germany. GSK would also acquire new manufacturing sites in India and China. In addition, the integration of the supply of a number of key antigens, currently provided to GSK by Novartis, will provide immediate improvements and enhance the future flexibility of the business, particularly in paediatric vaccines. Realising value for Oncology GSK has agreed to divest its marketed Oncology portfolio, related R&D activities and rights to its AKT inhibitor and also grant commercialisation partner rights for future oncology products to Novartis for an aggregate cash consideration of $16 billion. Up to $1.5 billion of this amount depends on the results of the COMBI-d trial, a Phase III study evaluating the safety and efficacy of the combination of Tafinlar (BRAF) and Mekinist (MEK) versus BRAF monotherapy. For GSK, this part of the Transaction represents a unique opportunity to crystallise an attractive value for its marketed portfolio and provide Novartis with the opportunity to leverage its global scale in this therapy area and deliver new growth and development opportunities for these products. GSK?s R&D in oncology will continue with programmes to investigate potential new treatments in areas of cancer immunotherapy, epigenetics, and tumour environment. Financial implications Sales and earnings benefits The proposed Transaction significantly exceeds GSK?s returns criteria and the company expects to realise benefits to sales and earnings as a result of it. The Transaction would increase overall GSK revenues by ?1.3 billion to ?26.9 billion, on a 2013 pro forma basis. The Transaction is expected to be accretive to core earnings per share from the first year, reflecting the execution of the intended B share scheme, and is expected to make a growing contribution to earnings thereafter, especially from 2017, as the delivery of cost savings, new product launches and re-introduction of Novartis? OTC products accelerates. GSK?s operating margins would reflect changes to GSK?s revenue mix which result from the Transaction. New revenue growth opportunities are expected in both Vaccines and Consumer Healthcare as a result of the Transaction and future revenues would also reflect the benefits from recent restructuring and investment by Novartis. In Consumer Healthcare, sales would reflect the re-supply of certain products manufactured at Novartis? facility in Lincoln, Nebraska following remediation activities at the site. Production and re-supply of these products is expected to increase and be phased in over the next 2 years. Cost savings GSK estimates that total annual cost savings of ?1 billion could be achievable by the fifth full year following closing. The delivery of these potential savings is expected to be phased with approximately 50% delivered by year three and the full amount by year five. GSK intends to reinvest approximately 20% of cost savings to support innovation and expected new product launches across the Group, wherever returns are most attractive. Total costs to deliver these savings are estimated to be ?2 billion, split approximately evenly between cash and non-cash charges. Contributions to the total cost savings are estimated to be approximately 40% from Consumer Healthcare, 40% from Vaccines and 20% from savings associated with the divestment of GSK?s Oncology portfolio. These estimates are subject to further detailed implementation planning post closing. Potential cost savings would be generated from reductions in selling and administrative costs, removal of infrastructure overlaps and reduced third party contracting as well as through improvements in manufacturing costs. The new GSK businesses would also expect to benefit from new economies of scale and earn greater returns from leveraging sales, distribution and purchasing opportunities across its broader global platform. The companies will conduct consultations on cost savings proposals with staff, works councils, trade unions and other employee representatives in line with local practice and in accordance with applicable employment legislation. Shareholder information Approvals The Transaction constitutes a Class 1 transaction for the purposes of the FCA?s Listing Rules and therefore is conditional upon the approval of GSK?s shareholders at a General Meeting which is expected to be held in the fourth quarter of 2014.? The Transaction is also conditional upon other matters, including receiving certain anti-trust approvals. Completion of the Transaction is anticipated to occur during the first half of 2015. Capital return GSK plans to use net after tax cash proceeds of $7.8 billion to fund a capital return of ?4 billion to shareholders following completion of the transaction. This return is expected to be implemented through a B share scheme in 2015, subject to approvals. Specific details related to the execution of the B share scheme will be sent to shareholders in due course. Following implementation of the B share scheme, GSK would not make any further share repurchases in 2015 but will review the potential for future share buy backs from 2016 in line with its usual annual cycle and subject to its current return and rating criteria. Teleconferences and Presentation A media teleconference will be held today at 7.30am BST: UK Free Phone:???????????????????????????????????????????????????????? 0800 783 0906 US Free Phone:???????????????????????????????????????????????????????? 866 804 8688 US Toll:??????????????????????????????????????????????????????????????????????718 354 1175 International Free Phone:??????????????????????????????????????? ??01296 480 100 Access Numbers:????????????????????????????????????????? http://www.btconferencing.com/globalaccess/?bid=54_attended Confirmation Code:?????????????????????????????????????????????????? ?452 996 Analysts/investors teleconferences will be held today at 10.30am and 3.00pm BST: UK Free Phone:???????????????????????????????????????????????????????? 0800 783 0906 US Free Phone:???????????????????????????????????????????????????????? 866 804 8688 US Toll:???????????????????????????????????????????????????????????????????????718 354 1175 International Free Phone:????????????????????????????????????????? ?01296 480 100 Access Numbers:????????????????????????????????????????? http://www.btconferencing.com/globalaccess/?bid=54_attended Confirmation Code:?????????????????????????????????????????????????? ??401 617 81 A presentation for analysts and investors is available on GSK?s website: www.gsk.com ? 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GSK ? one of the world?s leading research-based pharmaceutical and healthcare companies ? is committed to improving the quality of human life by enabling people to do more, feel better and live longer.? For further information please visit www.gsk.com   Information regarding forward-looking statements This announcement includes statements that are, or may be deemed to be, ?forward-looking statements?. These forward-looking statements can be identified by the use of forward-looking terminology, including the terms ?believes?, ?estimates?, ?plans?, ?projects?, ?anticipates?, ?expects?, ?intends?, ?may?, ?will?, or ?should? or, in each case, their negative or other variations or comparable terminology, or by discussions of strategy, plans, objectives, goals, future events or intentions. These forward-looking statements include all matters that are not historical facts. They appear in a number of places throughout this announcement and include, but are not limited to, statements regarding GSK?s intentions, beliefs or current expectations concerning, among other things, GSK?s business, results of operations, financial position, prospects, growth, strategies and the industry in which it operates as well as those of the Novartis businesses that are the subject of the transaction. By their nature, forward-looking statements involve risk and uncertainty because they relate to future events and circumstances. Forward-looking statements are not guarantees of future performance and the actual results of GSK?s operations and financial position, and the development of the markets and the industry in which GSK operates, may differ materially from those described in, or suggested by, the forward-looking statements contained in this announcement. The same applies in respect of the Novartis Businesses that are the subject of the transaction. In addition, even if the results of operations, financial position and the development of the markets and the industry in which GSK operates are consistent with the forward-looking statements contained in this announcement, those results or developments may not be indicative of results or developments in subsequent periods. A number of factors could cause results and developments to differ materially from those expressed or implied by the forward-looking statements including, without limitation, general economic and business conditions, industry trends, competition, changes in regulation, currency fluctuations, changes in its business strategy, political and economic uncertainty and other factors discussed in this announcement. Forward-looking statements may, and often do, differ materially from actual results. Any forward-looking statements in this announcement speak only as of their respective dates, reflect GSK?s current view with respect to future events and are subject to risks relating to future events and other risks, uncertainties and assumptions relating to GSK?s operations, results of operations and growth strategy. You should specifically consider the factors identified in this document, in addition to the risk factors that may affect GSK?s operations which are described under ?Risk Factors? in the Company?s 2013 Annual Report on Form 20-F, which could cause actual results to differ before making any decision in relation to the Transaction as well as those of the Novartis businesses that are the subject of the transaction. Subject to the requirements of the FCA, the London Stock Exchange, the Listing Rules and the Disclosure and Transparency Rules (and/or any regulatory requirements) or applicable law, GSK explicitly disclaims any obligation or undertaking publicly to release the result of any revisions to any forward-looking statements in this announcement that may occur due to any change in GSK?s expectations or to reflect events or circumstances after the date of this announcement. No statement in this document is intended as a profit forecast or profit estimate and no statement in this document should be interpreted to mean that the earnings per share of GSK, as altered by the Transaction will necessarily match or exceed the historical or published earnings per share of GSK or the relevant entities which form the basis for the Transaction ? This summary should be read in conjunction with the full text of this announcement. GlaxoSmithKline plc - Proposed 3-part transaction with Novartis Introduction GSK today announces that it has reached agreement with Novartis on a major 3-part transaction involving its Consumer Healthcare and Oncology businesses and Novartis? Vaccines and OTC (over-the-counter) Consumer Healthcare businesses. The Transaction with Novartis comprises three inter-conditional components, consisting of: (i)???????????? the creation of a Consumer Healthcare joint venture (JV), combining GSK?s Consumer Healthcare business and Novartis? OTC Consumer Healthcare business (the ?Consumer Healthcare Joint Venture?); (ii)??????????? the acquisition by GSK of Novartis? global Vaccines Business, including its meningitis portfolio and antigen manufacturing facilities, but excluding influenza vaccines (the ?Vaccines Acquisition?); and (i)???????????? the divestment of GSK?s marketed Oncology portfolio, related R&D activities and rights to its AKT inhibitor and the grant of commercialisation partner rights for future oncology products to Novartis (the ?Oncology Disposal?). Summary of principal terms and conditions of the Transaction This section provides information about the material terms and conditions of the Transaction, its constituent parts and the agreements entered into today by GSK and Novartis in that regard. Payment terms have been agreed in US dollars ($). Consumer Healthcare Joint Venture GSK and Novartis have today entered into contribution agreements under which, upon completion of the Transaction, GSK and Novartis will create the Consumer Healthcare Joint Venture to hold GSK?s Consumer Healthcare business and Novartis? OTC Consumer Healthcare business. In consideration of these contributions, GSK will have a controlling 63.5% equity interest in the joint venture company, with Novartis? interest being 36.5%. The JV will operate under the GSK Consumer Healthcare name and would operate in all territories where GSK and Novartis have a presence in those businesses, with the exception of India and Nigeria where GSK will continue to hold directly its interests in its listed subsidiaries. The JV will be consolidated in GSK?s financial statements and will have no external debt. GSK will assume control of Novartis? OTC manufacturing network. This includes Novartis? facility in Lincoln, Nebraska. Remedial actions to address the manufacturing issues identified at the Nebraska site have been underway since 2012 and re-supply of certain products started in November 2013. At present it is not possible to determine when the site will resume full operations. Production and re-supply of products is expected to increase and be phased over the next 2 years. The joint venture is the subject of a shareholders? agreement between GSK and Novartis, under which GSK will have 7 directors and Novartis 4 directors on the board of the joint venture company. GSK will have control of the joint venture company through the board, while Novartis will enjoy customary minority shareholder protections. Novartis has the right to exit its investment in the joint venture company via a put option to GSK at an expert-determined market valuation.? The put option is exercisable in certain windows in the period from the third to the twentieth anniversary of closing of the Transaction. The put option may be exercised either in respect of Novartis? entire holding in the joint venture company at any given point or in instalments of 7.5% (with a final instalment of 14%).?? If the put option is exercised in instalments, a waiting period of 18 months applies between option exercises. GSK and Novartis are subject to restrictions regarding the transfer of their respective interests in the joint venture company to third parties.? As an exception to these restrictions, Novartis will be free to sell its shares to a third party (subject to GSK?s right of first refusal) following expiry of the put option arrangements described above.? In addition, GSK is free to sell its shares to a third party following the third anniversary of closing of the Transaction, subject to Novartis having a right of first refusal and a tag right entitling it to require its shares to be sold as part of any sale by GSK. Vaccines Acquisition GSK and Novartis have today entered into a share and business sale agreement under which, upon completion of the Transaction, Novartis? global Vaccines Business (including relevant corporate entities but excluding influenza vaccines) will be sold to GSK. The consideration payable by GSK under this agreement comprises: (i)???????????? $5.25 billion payable at closing (which is subject to customary adjustment for levels of cash, debt and working capital); (ii)??????????? the following pipeline-related milestone payments: (a)? $450 million upon FDA regulatory approval for Novartis? MenABCWY vaccine product; (b)? $450 million in the event that Bexsero achieves an agreed annual net sales threshold; (c)? $450 million upon achievement of an agreed milestone relating to ACIP regulatory recommendations in respect of either Novartis? MenABCWY vaccine product or Bexsero; and (d)?? $450 million upon achievement of an agreed milestone relating to ACIP regulatory recommendations in respect of Novartis? Group B streptococcus vaccine (?GBS?); and (iii)?????????? annual royalty payments at the rate of 10% on certain net sales of the above products. Oncology Disposal GSK and Novartis have today entered into a sale agreement under which GSK has agreed to sell, upon completion of the Transaction, the rights to GSK?s currently marketed oncology portfolio, related R&D activities and its AKT inhibitor currently in development as well as to grant Novartis preferred partner rights for future commercialisation of GSK oncology products for an aggregate cash consideration of $16 billion. Up to $1.5 billion of this cash consideration depends on the results of the COMBI-d trial, a Phase III study evaluating the safety and efficacy of the combination of Tafinlar (BRAF) and Mekinist (MEK) versus BRAF monotherapy. COMBI-d is a Phase III trial studying the combination of BRAF/MEK in patients with unresectable or metastatic melanoma, as compared to BRAF monotherapy. The trial reported positive progression free survival (primary endpoint) data in January 2014, and is being continued to evaluate its secondary endpoint of overall survival. The data on overall survival is estimated to read out in late 2014 or early 2015. GSK will enter into a manufacturing supply agreement for the transferred products with Novartis for an initial period of 5 years. The cash consideration is subject to customary adjustment for levels of working capital. GSK will retain its early-stage R&D pipeline and discovery capability, as well as certain product rights outside of oncology for Arzerra. The preferred partner rights granted by GSK to Novartis are for a period of 12.5 years from closing of the Transaction and relate to co-development and commercialisation opportunities relating to GSK oncology development products. Inter-conditionality and Long-stop date The Consumer Healthcare Joint Venture, the Vaccines Acquisition and the Oncology Disposal are inter-conditional.? As such, none of the Transaction?s constituent parts will close unless the conditions to the other parts are satisfied or, where applicable, waived.? The various conditions to the Transaction and its constituent parts must be satisfied (or, where applicable, waived) within 18 months (or such other date as GSK and Novartis may agree).? If that does not occur, the Transaction will terminate. Conditions to completion The Transaction constitutes a Class 1 transaction for the purposes of the FCA?s Listing Rules and is therefore conditional upon the approval of GSK?s shareholders at a General Meeting. Until such time as the Transaction is approved by GSK?s shareholders, the Transaction is also conditional upon the Novartis Board not withdrawing approval of the Transaction that it has announced today. GSK has agreed that its Board will recommend that shareholders vote in favour of the resolution approving the Transaction at the General Meeting (the ?GSK Recommendation?).? The Novartis Board has today approved the Transaction as being in the best interests of Novartis and its shareholders as a whole (the ?Novartis Approval?).? The GSK Recommendation and the Novartis Approval are both subject to provisions that allow them to be withdrawn on account of fiduciary duties. In addition, the Transaction and its constituent parts are subject to certain other conditions, including the following material conditions: ????????? the receipt of anti-trust clearances by GSK and Novartis in respect of the constituent parts of the Transaction, including EU merger clearance and expiry of the HSR waiting periods; ????????? no material adverse event in relation to the businesses of either GSK or Novartis which are part of the Transaction; and ????????? certain other regulatory matters and approvals and certain third party consents. GSK and Novartis will also conduct consultations with staff, works councils and trade unions and other employee representatives as appropriate and in accordance with applicable requi