AstraZeneca has agreed to transfer its global rights to?Eklira?(aclidinium bromide), known as?Tudorza?in the US, and?Duaklir?(aclidinium bromide/formoterol) to Covis Pharma Group (Covis Pharma). Both medicines are delivered via the?Genuair?device and used for the treatment of patients with chronic obstructive pulmonary disease (COPD). The agreement will ensure continued patient access to these established medicines. Covis Pharma?previously?acquired the rights to the respiratory medicines?Alvesco,?Omnaris?and?Zetonna?from AstraZeneca in 2018. Financial considerations Covis Pharma will pay AstraZeneca $270m on completion. Covis Pharma will also cover certain ongoing development costs related to the medicines. The income arising from the upfront payment will be fully offset by a charge for derecognition of the associated intangible asset and therefore no Other Operating Income will be recognised in AstraZeneca?s financial statements. In 2020,?Eklira?and?Duaklir?generated AstraZeneca revenue of $143m in the countries covered by this agreement. The transaction is expected to close in the fourth quarter of 2021, subject to customary closing conditions and regulatory clearances. The agreement will not impact the Company?s financial guidance for 2021. Eklira?and?Duaklir Eklira?(aclidinium bromide) and?Duaklir?(aclidinium bromide/formoterol) are inhaled respiratory medicines used for the maintenance treatment of COPD.?Eklira?is a long-acting muscarinic antagonist (LAMA), which is marketed in the US as?Tudorza?and in some countries as?Bretaris.?Duaklir?is a combination therapy that contains both a LAMA and a long-acting beta2-agonist (LABA). It is marketed in some countries as?Brimica. Both medicines are presented as a dry powder for inhalation and are delivered via a breath-actuated multi-dose dry powder inhaler,?Genuair?(Pressair?in the US). AstraZeneca licensed the global rights to both products from Almirall S.A. in 2014. AstraZeneca AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit?astrazeneca.com?and follow the Company on Twitter?@AstraZeneca. Contacts For details on how to contact the Investor Relations Team, please click?here. For Media contacts, click?here.

Adrian Kemp Company Secretary AstraZeneca PLC