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BridgeBio Pharma Reports Results of BBP-418 in P-II Study for the Treatment of Limb-girdle Muscular Dystrophy Type 2i

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BridgeBio Pharma Reports Results of BBP-418 in P-II Study for the Treatment of Limb-girdle Muscular Dystrophy Type 2i

BridgeBio Pharma Reports Results of BBP-418 in P-II Study for the Treatment of Limb-girdle Muscular Dystrophy Type 2i

Shots:

  • The P-II study evaluates BBP-418 in 14 patients including ambulatory & non-ambulatory with LGMD2i. The results showed a 43% increase in the ratio of αDG to total αDG from baseline across all 3 dosing cohorts, 70% reduction in CK @90 day in all cohorts & 77% @180 day for cohorts 1 & 2
  • Additionally, 11 patients received a 50% reduction in CK with 75% reaching 2x the normal range suggested a reduction in muscle breakdown, increase in 10MWT velocity @90 & 180 days, was well-tolerated with no treatment-related serious AEs, dose-limiting toxicities or discontinuations were identified
  • The company plans to meet with regulatory authorities in 2022 to discuss the paths for approval and plans to initiate a P-III trial in H2’22

Ref: Globe Newswire | Image: Bridgebio

Click here to­ read the full press release 

Neha

Neha Madan is a content writer at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots.

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