Chi-Med and BeiGene Collaborate to Evaluate the Combinations of Surufatinib and Fruquintinib with Tislelizumab for Solid Tumors
Shots:
- The two companies collaborated to evaluate the safety- tolerability and efficacy of Chi-Med’s surufatinib and fruquintinib- with BeiGene’s tislelizumab against multiple solid tumor cancer indications in the US- EU- China and Australia. Both the companies will mutually supply drug and other support
- Tislelizumab is an anti PD-1 mAb- specifically designed to minimize binding to FcγR- which is believed to play an essential role in activating phagocytosis in macrophages- to minimize its negative impact on T effector cells while fruquintinib improves kinase selectivity against VGEFR to minimize off-target toxicities
- Surufatinib is a VEGFR inhibitor- inhibits CSF-1R- blocks the accumulation of tumor-associated macrophages and promoting infiltration of T effector cells into tumors- leading to possible synergistic anti-tumor activity with PD-1 inhibitors
Click here to read full press release/ article | Ref: Business wire | Image: BeiGene
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