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Takeda's Alunbrig (brigatinib) Receives EC's Approval as a 1L Treatment for ALK+ Advanced Non-Small Cell Lung Cancer

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Takeda's Alunbrig (brigatinib) Receives EC's Approval as a 1L Treatment for ALK+ Advanced Non-Small Cell Lung Cancer

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  • The EC’s approval is based on P-III ALTA-1L study assessing Alunbrig (180mg- qd with seven-day lead-in at 90mg- qd) vs crizotinib (250mg- bid) in 275 patients with ALK+ LA/m-NSCLC prior not treated with an ALK inhibitor
  • The P-III ALTA-1L study results: Alunbrig showed superiority in anti-tumor activity- @2+yrs. follow up- reduction in risk of intracranial disease progression or death by 69% in patients with brain metastases- PFS (24.0 vs 11.0mos.) as assessed by BIRC and (29.4 vs 9.2mos.) as assessed by investigators
  • Alunbrig is a potent and selective TKI inhibitor- designed to target and inhibit ALK fusion protein in NSCLC and has received the US FDA’s accelerated approval in Apr’2017. The EC’s approval follows CHMP’s positive opinion on Feb 27- 2020

Click here ­to­ read full press release/ article

 Ref: PRNewswire | Image: Takeda


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