AstraZeneca Reports Results of Calquence (acalabrutinib) in P-III ELEVATE TN Study for Previously Untreated Chronic Lymphocytic Leukemia

 AstraZeneca Reports Results of Calquence (acalabrutinib) in P-III ELEVATE TN Study for Previously Untreated Chronic Lymphocytic Leukemia

AstraZeneca Reports Results of Calquence (acalabrutinib) in P-III ELEVATE TN Study for Previously Untreated Chronic Lymphocytic Leukemia

Shots:

  • The P-III ELEVATE TN study involves assessing of Calquence + obinutuzumab / Calquence as monothx. vs chlorambucil + obinutuzumab in 535 patients in a ratio (1:1:1) with previously untreated CLL aged ≥65yrs. or b/w 18-65yrs. with CIRS> 6 or creatinine clearance of 30-69 mL/min
  • Results: @24mos.patients remained free of disease progression or death (93%/ 87% vs 47%); ORR (93.9% /85.5% vs 78.5%); OS (5%/ 6.1% vs 9.6%); AEs (11.2%/ 8.9% vs 14.1%); @ median follow-up of 28.3 mos., reduction in diseases progression or death (90% vs 80%) in both combinations i.e,  Calquence + obinutuzumab vs chlorambucil + obinutuzumab respectively
  • Calquence is a BTK inhibitor, act by binding covalently to BTK further inhibiting its activity in the beta cell and is an approved therapy for MCL who have received at least one prior therapy and was approved under accelerated review in the US

Click here to­ read full press release/ article | Ref: AstraZeneca | Image: Delaware Business Now

Tuba Khan

Tuba Khan is Senior Editor at PharmaShots. She is curious, creative, and passionate about recent updates and innovation in the Life sciences industry. She covers Biopharma, MedTech, and Digital health segments. Tuba also has an experience of digital and social media marketing and runs the campaigns independently. She can be contacted on tuba@pharmashots.com

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