- The P-III PEMPHIX study involves assessing of MabThera/Rituxan vs Mycophenolate Mofetil (MMF) in patients with moderate to severe active PV, requiring 60-120 mg/day oral prednisone (or equivalent) for 52wks.
- The P-III PEMPHIX study results: met its 1EPs i.e, superior to MMF in achieving sustained CR without using steroids for 16+ consecutive wks. (40.3% vs 9.5%); met its 2EPs i.e, low cumulative oral corticosteroid dose, fewer flares, greater sustained CR, the lesser likelihood of flare, improvement in DLQI
- MabThera/Rituxan targets CD20, indicated to treat GPA & MPA in combination with glucocorticoids in adults & children & used to treat RA in combination with MTX and has received FDA & EMA’s approval for PV in Jun’18 & Mar’19 respectively
Click here to read full press release/ article | Ref: Roche | Image: Cartom