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Health Canada Approves AstraZeneca’s Imfinzi to Treat Limited-Stage Small Cell Lung Cancer (LS-SCLC)

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  • Health Canada has approved Imfinzi monotx. for the treatment of LS-SCLC adults whose disease has not progressed after receiving Pt-based CRT
  • Approval was based on P-III (ADRIATIC) trial (n=730) assessing Imfinzi (1500mg, IV, Q4W) with or without Imjudo (75mg, IV, Q4W × 4 cycles) followed by Imfinzi (for ~24mos.) vs PBO
  • Study showed reduced risk of death by 27% (mOS: 55.9 vs 33.4mos.), where 57% vs 48% pts were alive at 3yrs., while also depicting improved PFS by 24% (mPFS: 16.6 vs 9.2mos.), where 46% vs 34% pts had no disease progression at 2yrs. Data was presented at ASCO 2024 & published in The NEJM

Ref: Newswire | Image: AstraZeneca

Related News:- AstraZeneca and Daiichi Sankyo Receive the EC’s Approval for Datroway to Treat HR+/HER2- Breast Cancer

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