Shots:

• The P-III PROfound study involves assessing of Lynparza (olaparib) vs Enzalutamide/Abiraterone in men with mCRPC and have progressed on prior treatment with anti-cancer therapies with HRRm gene mutation
• The P-III PROfound study resulted in meeting its 1EPs i.e- improvement in radiographic PFS in men with mCRPC selected for BRCA1/2 or ATM gene mutations- safety & tolerability profiles were consistent with the previous study 
• Lynparza is a PARP inhibitor act by blocking DNA damage response in tumors harboring HRR mutation including BRCA1/BRCA2. AstraZeneca and MSD are also evaluating Lynparza for prostate cancer and as a 1L therapy in ongoing P-III PROpel study in combination with abiraterone for mCRPC

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Ref: AstraZeneca | Image: AstraZeneca