Hoth Therapeutics Reports Preclinical Results of HT-KIT in Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia
- The research was conducted at NC State University to evaluate the efficacy of HT-KIT in cancerous and non-cancerous cells. Results demonstrated that HT-KIT effectively kills human mast cells that rely on signaling through the KIT receptor to survive and the effect of single-dose lasted for about 2wks. while reducing KIT expression lasted for 7days
- The result also demonstrated its potential to reduced KIT expression using GIST cells and kill within 48 and 72hrs. along with lower KIT expression in the AML cells over 72hrs. as well.
- HT-KIT is an antisense oligonucleotide that targets the proto-oncogene cKIT being developed for the treatment of mast cell-derived cancers and anaphylaxis and previously received ODD from the US FDA
Ref: PR Newswire | Image: Hoth Therapeutics
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