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Roche Reports Results of Ocrevus (ocrelizumab) in Three P-III Studies for Relapsing and Primary Progressive Multiple Sclerosis

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Roche Reports Results of Ocrevus (ocrelizumab) in Three P-III Studies for Relapsing and Primary Progressive Multiple Sclerosis

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  • The P-III OPERA- ORATORIO and OBOE studies result involves assessing of Ocrevus (ocrelizumab) vs PBO in patients with RMS and PPMS- presented at AAN Annual Meeting
  • Results: reduction in risk of disability progression associated with exposure and lower B-cell levels & permanent disability progression; @24wks. reduction in CDP; @48wks. RMS- PPMS patients with CDP treated with Ocrevus vs switched to Ocrevus- (10.4 %- 43.7% vs 15.7%- 53.1%); @12- 24 & 52 wks. in RMS reduction in nerve cell damage- inflammation biomarker in serum and CSF
  • Ocrevus (ocrelizumab- IV) is a mAb targeting CD20+ B cells- administered every 6mos. and is approved in 85 countries including NA- SA- Eastern Europe & EU for both RMS & PPMS

Ref: Roche | Image: Roche

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