Roche's Tecentriq + Avastin Receive FDA's Breakthrough Designation as 1L Treatment for Advanced or Metastatic Hepatocellular Carcinoma (HCC)
Shots:
- The FDA’s BT designation is based on P-Ib (NCT02715531) study assessing Tecentriq (1200mg) + Avastin (15 mg/kg) in 23 patients with advanced or metastatic first-line HCC
- The P-Ib study results: median follow-up of 10.3 mos. as per RECIST v1.1 (65%); response rate (61%); PFS- DOR- TTP- & OS not reached follow up of 10.3 mos.; no new safety signals
- Tecentriq (atezolizumab) + Avastin (bevacizumab) is a combination therapy- Tecentriq inhibit VEGF to restores anti-cancer immunity & Avastin shows anti-angiogenic effects enhancing the effect of Tecentriq
Ref: Roche | Image: Roche
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