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Exelixis' Cabometyx (cabozantinib) Recommended by the NCCN in its Clinical Practice Guidelines for advanced RCC despite of patient risk status

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Exelixis' Cabometyx (cabozantinib) Recommended by the NCCN in its Clinical Practice Guidelines for advanced RCC despite of patient risk status

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  • Guidelines for Kidney Cancer: CABOMETYX (TKi) is recommended for 1L RCC patients in the poor- and intermediate-risk groups (Category 2A)- 1L treatment for favourable-risk patients (Category 2B)- and for previously treated patients (Category 1)
  • The (Category 2A) guidelines are based on P-II CABOSUN trial (N=157) in (ratio 1:1) administering cabozantinib (60mg qw)/sunitinib (50mg qw-4 wks. with 2 wks. off) showing improved PFS results in trial
  • Additionally- FDA has accepted cabometyx’s sNDA for previously treated advanced HCC (Child-Pugh Class A only) with PDUFA date of 14 Jan- 2019

/ article | Ref: Exelixis | Image:  Glassdoor

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